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KMID : 0363620100310030128
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Journal of Korean Oriental Medicine
2010 Volume.31 No. 3 p.128 ~ p.132
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Review for Herbal Drug and Drug-Induced Liver Injury
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Park Bong-Ky
Son Chang-Gue
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Abstract
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Objectives: This study aimed to review the general features of drug induced liver injury (DILI) and the important factors in consideration of herbal drugs and DILI.
Methods: We reviewed general aspects of DILI such as classification, inducible factors, diagnosis methods, prevention, and the status of herbal drug-associated DILI via literature.
Results: Besides the drug itself, genetic and environmental factors affect hepatic toxicity. There is a lack of definitive diagnoses of DILI by drugs, including herbal remedies. The possibility of herbal drug-associated DILI is exaggerated, and majority of herbal drug-derived hepatic injury could be easily prevented if Oriental doctors pay attention to this issue.
Conclusion: This study can provide Oriental doctors an overview and be helpful in minimizing the episodes of hepatotoxicity in use of herbal drugs.
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KEYWORD
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Drug-induced liver injury, herbal drug, traditional Korean medicine
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